Option A
NAD+ IV Infusion
250-1,000 mg of NAD+ delivered slowly via IV over 2-4 hours, typically in a series of 4-10 daily sessions for repletion.
The Full Service PageNashville BiohackingCompare
NAD+ IV vs. NAD+ Shots
NAD+ levels decline roughly 50% between ages 40 and 60. Replenishing it is one of the most-discussed longevity interventions. The two main delivery methods are intravenous infusions and subcutaneous shots — they share the same compound but feel completely different in practice.
Option B
NAD+ Shots
100-250 mg of NAD+ injected subcutaneously in under 2 minutes, typically 1-3× per week for maintenance.
The Full Service Page
Side by Side
How they compare on the details that matter.
| Attribute | NAD+ IV Infusion | NAD+ Shots |
|---|---|---|
| Dose per Session | 250-1,000 mg | 100-250 mg |
| Duration per Session | 2-4 hours | Under 2 minutes |
| Frequency | Daily for 4-10 sessions, then maintenance | 1-3× per week ongoing |
| Onset of Effect | Often noticeable in the first 1-2 sessions | Cumulative over 2-4 weeks |
| Intensity | Initial sessions can feel intense (heavy chest, flushing); slowing drip resolves it | Mild — brief sting at injection site, minimal sensation |
| Cost per Session | Higher — reflects dose, IV setup, time | Lower — designed for maintenance |
| Best For | Repletion (post-illness, addiction recovery, chronic fatigue, depleted baseline) | Maintenance, busy schedules, ongoing optimization |
| Time Commitment | Significant — half a day per session | Trivial — can do during a lunch break |
Which to Pick
The honest recommendation.
Pick NAD+ IV Infusion
Choose NAD+ IV if you're profoundly depleted — post-illness, severe fatigue, addiction recovery, or chronic stress that's not responding to other interventions. The high single dose moves the needle faster.
Pick NAD+ Shots
Choose NAD+ shots if you're at functional baseline and want ongoing optimization. Lower friction, lower cost, fits any schedule, and cumulative effects show up over weeks.
Do Both
Many members use an initial IV series (4-10 sessions) for repletion, then transition to a shot maintenance routine 1-3× per week. This pattern captures the rapid response of IV with the long-term sustainability of shots.
Common Questions
Questions about the comparison.
Do shots work as well as IVs?
For maintenance, yes — many members feel and function just as well on a 1-3×/week shot routine as they would on monthly IVs. For repletion (severely depleted baseline, post-illness, chronic fatigue, addiction recovery), the higher single doses delivered by IV are typically more effective in the short term.
Why does NAD+ IV feel so intense?
When NAD+ levels are depleted, the cells absorb the arriving NAD+ rapidly and use it immediately for energy and DNA repair. The systemic response can feel like a pressure on the chest, flushing, or mild nausea. None of this is dangerous; slowing the drip rate resolves the sensation within seconds. Most members find subsequent sessions noticeably easier as cellular function normalizes.
How do I know if I'm depleted enough for IV vs. just maintenance shots?
Bloodwork doesn't directly measure NAD+ status, but symptoms tell the story. Profound fatigue with normal sleep, brain fog that doesn't lift, post-viral recovery struggles, or recent illness all point toward IV-level repletion. If you feel generally well and want to maintain healthy levels, shots are typically the better fit.
Is there a risk of overdoing NAD+?
The body has strong regulatory mechanisms for NAD+ metabolism, and excess is excreted. The clinical risk profile is favorable at standard doses. The bigger consideration is whether the spend matches the benefit — for most adults at baseline, shots provide most of the value at a fraction of the cost.