Nashville BiohackingWith Scott Crosbie
The ApproachCellular Energy

NAD+ TherapyNAD IV Therapy · NAD+ Infusion · NAD Shots

NAD+ Therapy is the intravenous or injectable replenishment of nicotinamide adenine dinucleotide — a coenzyme central to cellular energy production and DNA repair whose levels decline by roughly 50% between ages 40 and 60.

A relaxed nutrient therapy session at Next Health Nashville

At a Glance

Duration
IV: 2–4 hours per session. Subcutaneous shots: under 2 minutes.
Frequency
IV: blocks of 4–10 daily sessions for repletion, then monthly maintenance. Shots: 1–3× per week as needed.
Best For
Mental clarity, sustained energy, cellular resilience, addiction recovery support, post-illness recovery
Session Feels Like
IV: slow drip can feel intense (tight chest, flushing) — slowing the drip resolves it. Shots: brief sting, then minimal sensation.

In Practice

Replenishing the molecule your cells depend on to produce energy and repair.

NAD+ (nicotinamide adenine dinucleotide) is essential to how cells generate energy, repair DNA, and regulate aging. Levels fall steadily over the decades. Intravenous NAD+ therapy restores this coenzyme directly, and is increasingly explored for mental clarity, sustained energy, and cellular resilience.

  • Supports mitochondrial energy production
  • Aids cellular and DNA repair processes
  • Associated with mental clarity and focus
  • A cornerstone of modern longevity protocols

What It Addresses

Concerns this helps with.

  • Age-related cellular energy decline
  • Mental fatigue and brain fog
  • Chronic fatigue
  • Addiction recovery (adjunct)
  • Post-illness or post-anesthesia recovery
  • Athletic performance plateaus

Common Questions

Common questions, answered straight.

What does NAD+ do in the body?

NAD+ is a coenzyme present in every cell. It's central to the production of ATP (your cells' energy currency), to DNA repair, and to the function of sirtuins — a family of enzymes involved in cellular aging. Levels decline steadily with age, which is one reason NAD+ replenishment is studied so heavily in longevity research.

Why does NAD IV feel intense at first?

When NAD+ levels are depleted, the first infusions can produce a heavy, pressured chest sensation — almost like an elephant sitting on you — along with flushing or mild nausea. This is not danger; it's the body actively using the NAD+ as it arrives. Slowing the drip rate resolves the sensation in seconds. Most members find subsequent sessions much milder as cellular function comes back online.

What's the difference between NAD IV and NAD shots?

NAD IV delivers a much larger dose (250–1,000 mg) over 2–4 hours and is preferred for repletion protocols and post-illness recovery. NAD shots (subcutaneous, typically 100–250 mg) take under two minutes and are excellent for maintenance — many members use them 1–3× per week as part of an ongoing routine.

Is NAD+ therapy worth the time investment?

Honest answer: it depends on the protocol and your starting state. Members who are profoundly depleted (post-illness, chronic fatigue, addiction recovery) often report dramatic clarity within a single session block. Those at relative baseline tend to notice subtler benefits — sharper focus, easier mornings, smoother recovery — over a few weeks of consistent dosing.

Book NAD+ Therapy

Available at both Next Health locations.

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